Cold Atmospheric Plasma and its Research Progress in Promoting Skin Wound Healing

doi:10. 3969 / j. issn. 1006-6179. 2022. 06. 017

Laboratory Animal Science ›› 2022, Vol. 39 ›› Issue (6): 96-103.DOI: 10. 3969 / j. issn. 1006-6179. 2022. 06. 017

( 1. Laboratory Animal Center, Dalian Medical University, Dalian 116044,China)( 2. Department of Gastroenterology, People’ s Hospital, Peking University, Beijing 100034,China)

Received:2021-01-13 Online:2022-12-28 Published:2023-01-13

冷等离子体及其在促进皮肤伤口愈合中的研究进展

( 1. 大连医科大学实验动物中心,大连 116044) ( 2. 北京大学人民医院胃肠外科,北京 100034)

通讯作者: 王爱国( 1970—) ,男,教授,研究方向:等离子体医学;肿瘤分子生物学. E-mail: wangaiguotl@ hotmail. com 王靖宇( 1964—) ,男,教授,研究方向:动物行为学;等离子体医学. E-mail: wangjingyus@ 163. com
作者简介:刘阳( 1994—) ,女,硕士,研究方向:等离子体医学及肿瘤分子生物学. E-mail:1667564110@ qq. com

Abstract

Abstract: Skin wound healing has always been the focus of the medical community. Since the 21st century, the rapid development of cold atmospheric plasma ( CAP ) medicine has provided an excellent treatment method for promoting the healing of skin wound. In this review, the CAP related concept and classification, generation and use method, and its application in medicine is briefly summarized. Further, the relevant molecular mechanisms of CAP in promoting wound healing phases including coagulation, inflammation, migration / proliferation, and remodeling are emphatically reviewed.

Key words: cold atmospheric plasma (CAP) , plasma medicine, skin wound healing

摘要： 皮肤伤口的愈合一直是医学界关注的焦点。21 世纪以来,冷等离子体医学的快速发展为促进皮肤伤口的愈合提供了优良的治疗手段。本文就冷等离子体的概念和分类、产生和使用方法及其在医学中的应用进行了简要概述。在此基础上,着重综述了冷等离子体在促进伤口凝血期、炎症期、迁移 / 增殖期、重塑期进展的相关分子机制。

关键词: 冷等离子体, 等离子体医学, 皮肤伤口愈合

CLC Number:

R454
Q95-3

LIU Yang, GUO Peng, ZHANG Nan, WANG Fujin, WANG Jingyu, WANG Aiguo. Cold Atmospheric Plasma and its Research Progress in Promoting Skin Wound Healing[J]. Laboratory Animal Science, 2022, 39(6): 96-103.

刘阳, 郭鹏, 张楠, 王福金, 王靖宇, 王爱国. 冷等离子体及其在促进皮肤伤口愈合中的研究进展[J]. 实验动物科学, 2022, 39(6): 96-103.